Press Release [2000 ~ 2001]

	[November 7, 2001]
	Fibroblast cell collagen secretion multiplies a few dozen times by combined use of trehalose-stabilized royal jelly and vitamin C.

Hayashibara Biochemical Labs., Inc. has been successful in enhancing the fibroblast cells collagen secretion a few dozen times by using trehalose stabilized royal jelly and vitamin C in combination and maintaining the secretion continuously for longer periods. Applications for patents have already been filed. Hayashibara Biochemical Labs., has also developed in the past the technology to stabilize vitamin C ( ascorbic acid) which is called AA-2G . By using the above mentioned two technologies it has now become possible as a result that one's own cells in the body will secrete few dozen times more collagen and it won't be necessary to ingest any biologically derived collagens from outside. Thus it will be possible to safely and economically maintain the beauty and health and to avoid the wrinkles and sagging of the skin. Moreover, it is expected that the technologies will also lead to the epoch making new products development in food and cosmetics fields.

	[October 23, 2001]
	Worldwide Development of Trehalose Conclusion of an Agreement with Major Sugar Manufacturer, British Sugar- Approved as Novel Food in the EU -

Hayashibara Company, Ltd. and British Sugar plc announced today that they had signed an Agreement for the production, marketing and sales of Hayashibara trehalose, a natural sugar, in Europe. The territory may be expanded to Middle East and Africa. The Commission of the European Union in September this year officially approved trehalose, produced by the patented Hayashibara method, as a Novel Food. British Sugar will commence marketing and sales activities for trehalose immediately. The company is already offering a pharmaceutical and cosmetic grade of trehalose. The agreement also allows British Sugar further evaluate the market potential and application of Hayashibara trehalose before making a decision by both parties to produce trehalose locally.

	[October 17, 2001]
	Completion of the Great Ape Research Institute (GARI) of Hayashibara Museum of Natural Sciences.

At Desaki peninsula in Okayama prefecture, Hayashibara Group has built the Great Ape Research Institute attached to Hayashibara Museum of Natural Sciences and completed in August 2001. Built in a luxuriant landscape, the 7,400m2 -research center has state-of-the-art facilities used for innovative research on the behavior of apes. The ongoing research in the institute (the biggest of the world of its kind) is of paramount importance for a better understanding of human kind in the 21st century. At GARI, 5 chimpanzees are now undergoing an original training and are subject of a multidisciplinary research program. The institute will be a place for primatologists from around the world to exchange information and experience. Moreover, the results of the research will be shared with the local community through jointly organized educational activities. We hope that the creation at Desaki peninsula in Tamano City of an institute opened to the rest of the world will significantly contribute to the promotion and revitalization of the region.

	[September 5, 2001]
	Hayashibara Walker released. Hayashibara Group's in-house magazine on CR-ROM

Hayashibara Co. Ltd. has started the release of a digitalized Company News CD-ROM called Hayashibara Walker for its employees. The CD-ROM has its essence from our homepage, and aims at informing the personnel (in an intelligible way) of the latest news in the company through moving pictures and sound. Produced for a broad audience, the CD-ROM is distributed to the employees of each department and can be played back either in the office or at home. Hayashibara Walker is released 4 times a year (spring, summer, autumn and winter) with a constantly enriched content.

	[August 21, 2001]
	Hayashibara Glucosamine IT. A New product on sale.

The Laboratory of Life Science of Hayashibara Group has developed a nutritional supplement made of glucosamine, form of an amino sugar that enters in the composition of the tissues of living bodies. Hayashibara Glucosamine IT will be on sale from September 1st this year. We seize this opportunity to launch the new form of 4 of our products: Hayashibara Akagin, Sanyunosei, Chinese Parsley, and Japanese Indigo. Their powered form is now available in an easy-to-use tablet form.

	[August 6, 2001]
	2001 Hayashibara Forum/SAGA-4th International Symposium on "Evolutionary Neighbors"

As part of their philanthropic activities, Hayashibara Foundation and SAGA (Support for African/Asian Great Apes), in collaboration with Hayashibara Museum of Natural Sciences and Jane Goodall Institute-Japan, will organize the Hayashibara Forum/SAGA-4th International Symposium on "Evolutionary Neighbors" in Okayama City from September 15 to 17. The Symposium will gather about a hundred primatologists, zoo caretakers and ecologists from Japan as well as from abroad, engaged in several research fields related to great apes. One of the main agendas to be discussed in-depth by the participants will be the improvement of primates' welfare, an issue of prime importance.

	[August 6, 2001]
	Roots and Shoots

Concomitantly with Hayashibara Forum/Saga-4th International Symposium on "Evolutionary Neighbors", Hayashibara Museum of Natural Sciences and Jane Goodall Institute Japan will sponsor the implementation of the program Roots & Shoots by Dr Jane Goodall in Okayama city on November 16, 2001.

	[July 4, 2001]
	Successful development of a fire-resistant storage technology for the protection of art works. Temperature rise inhibited by trehalose and ceramic fiber.

Hayashibara Biochemical Laboratories Inc. and Isolite Insulating Products Co. Ltd. have succeeded in the development of a fire-resistant storage technology and lightweight fire-resistant safe has been also developed. Patent for the technology has been filed. This technology uses the endothermic characteristics of trehalose, a natural saccharide, in the 90-130oC-temperature range. Concretely, the temperature rise in the fire-resistant safe was remarkably inhibited by using trehalose as a material to prevent temperature rise, and ceramic fiber as a fire-resistant and thermal insulation material. The technology prevents the discoloration of artwork's raw materials (which are usually not fire resistant) at permissible temperature and time (130oC and 6 hours, respectively). Moreover it makes possible the manufacture of a light, compact and brand new fire-resistant safe that can be easily moved in case of emergency. With its outstanding fire-resistant and heat insulation properties, the safe can be used for the storage of art works in museums. Moreover, it has various applications as a fire-resistant safe that can be used in companies as well as in ordinary houses. From now on, Isolite Insulating Products Co. Ltd. will manufacture the safe, and Hayashibara will take charge of the marketing and sale of the new product.

	[March 16, 2001]
	Collaboration of "Digital Museum-Dinosaur Factory-".

Hayashibara Museum of Natural Science of Hayashibara Group and Matsushita Electric Indutrial Co., Ltd. plan to develop new cultural facility "Digital Museum-Dinosaur Factory-" inside "Panasonic Center" which will be a base for receiving and sending information and will open in the autumn 2002. The museum is designed to foster children's creativity, satisfy their curiosity and spirit of inquiry, and share the joy of discovery in the process of dinosaur research. The facility will be a new type of museum where each guest can easily obtain information, utilizing state-of-the-art digital technology from Matsushita, about specimens of dinosaur fossils and research results in the possession of Hayashibara Museum of Natural Sciences.

	[March 8, 2001]
	Held a charity for childhood cancer called "Takeshi Kakehashi piano concert".

Hayashibara Foundation will hold the first charity for childhood cancer called "Takeshi Kakehashi piano concert" (Sponsored by Hayashibara Foundation/Supported by Asahi Broadcasting) at the Symphony Hall in Osaka from 7pm on April 13 (Fri). The concert is a part of activities of "Hayashibara=Takeshi Kakehashi Foundation for Childhood Cancer" established by Hayashibara Foundation to support child cancer patients. 100 junior high school or high school students will be invited to the concert as guests of Hayashibara. It is anticipated that young people will appreciate the excellence of the classic music and artists who are internationally recognized for their talents, although this individuals have themselves suffered childhood cancer.

	[March 1, 2001]
	Established "Hayashibara=Takeshi Kakehashi Foundation for Childhood Cancer".

The Hayashibara Foundation has recently established "Hayashibara=Takeshi Kakehashi Foundation for Childhood Cancer" in cooperation with a pianist, Takeshi Kakehashi, who has leant his name and is taking an active role in the Foundation. Mr. Kakehashi has suffered and overcome the effects of childhood cancer. The purpose of this foundation is to demonstrate that childhood cancer can be overcome and that individuals can lead successful and productive lives in all fields of life, particularly in the arts. Individuals talented in this area will be awarded scholarships to pursue their talents. The Hayashibara Foundation hopes that many people will understand the importance of these activities and offer their support.

	[February 8, 2001]
	Hayashibara in worldwide license and supply agreement with Phizer useing PULLULAN for oral use. ~ Worldwide Development of Pullulan Now Started ~

Hayashibara Biochemical Labs., (HBL) of Okayama, Japan announced that it has been working with Pfizer Inc. of New York, USA since 1997 under the terms of a License and Supply Agreement. Pursuant to that agreement, HBL granted Pfizer a worldwide license to commercialize and market film-based oral care products containing HBL's patented pullulan and has commenced supplying the pullulan powder to Warner-Lambert Company, a subsidiary of Pfizer Inc. Pfizer has already introduced the film form oral care product in Canada under the brand name Listerine, and has plans to launch the product into other world markets.

	[January 18, 2001]
	Initiated full-scale manufacturing of edible film of natural polysaccharide (pullulan film).

Hayashibara Co., Ltd. has recently established a manufacturing facility and started to produce edible film made of pullulan, a natural polysaccharide, at Okayama plant 2 at Imabo. Hayashibara Co. started manufacture of pullulan in roll form (which Oosaka kagaku gokin manufactured before) and will sell the product as Hayashibara's product.

	[December 6, 2000]
	Released a new product of perfume and incense sticks called "Kotoba no Hana" which reproduces smell of natural aloeswoods.

Hayashibara Arts Mint Co., Ltd. of Hayashibara Group reproduced the smell of aroeswood chips "Kyara", which Hayashibara Museum of Art possesses, and developed a new product of perfume and incense sticks called "Kotoba no Hana". Hayashibara Arts Mint will market the new product starting December 25 of this year. Aroeswood chips and the smell of aroewoods are highly valued and are considered to be one of the most prestigious incense fragrances.

	[November 29, 2000]
	Implementation of 30th anniversary campaign of low-calorie sweetener "Marvie".

H+B Life Science Co., Ltd. of Hayashibara Group will start a nationwide 30th anniversary campaign of low-calorie sweetener "Marvie" from November 2000 to March 2002. From this campaign, all products of "candies" and "jams" will be increased 10〜15% in size as a token of the company's appreciation of customer loyalty.

	[September 12, 2000]
	Construction of "Great Ape Research Institute (GARI)" of Hayashibara Museum of Natural Sciences.

Hayashibara Museum of Natural Sciences established the Great Ape Research Institute (GARI) at Tamano City, Okayama. This institute, with abundant natural surroundings and state-of-the-art research equipment, will be the biggest facility and a world class location for anthropoid research. It is felt that facility will develop information that will of great interest for humans as we proceed into the 21th century. The construction will start January 2001 and finish by the end of June 2001. After the completion of the facility, training and research will be implemented. At the same time, the facility is designed to become a center for anthropoid research where scholars can exchange information and the research results will be applied to community education.

	[September 11, 2000]
	Trehalose prevents occurrence of odor specific to middle or aged people. -prevent occurence of substance causing body smell specific to the aged-

Hayashibara Biochemical Labs., Inc. found that Trehalose, a natural saccharide, possesses the capacity to prevent the creation of substances that cause body odor, and completed patent applications pertaining this function. Trehalose functions as a preventative-substance of body odor from the surface of skin and sweat. Trehalose is especially effective in preventing the occurrence of odor associated with aging. Trehalose can be widely applicable to products such as odor-care products which are directly applied to the skin, or indirectly using cosmetics and sanitary products, or treated undergarments. The application for elderly assistance aids, such as wheelchairs and mechanical beds, is also anticipated. Furthermore, various application technologies are being developed to make products that can take advantage of this interesting property.

	[September 4, 2000]
	Chinese parsley prevents accumulation of lead! Effect of mitigating lead poisoning is confirmed. Corroborated by biological test using mouse. Officially announced in Japanese Society of Pharmacognosy on September 8, 2000.

Hayashibara Biochemical Labs., Inc. confirmed that Chinese parsley prevents accumulation of lead and to mitigate lead poisoning. This is a first time to corroborate the effects of Chinese parsley by biologocal test. Furthermore, the result of the test will be officially announced in Japanese Society of Pharmacognosy on September 8 (the Society will be held from September 7 to September 8).

	[August 10, 2000]
	First time in the world! Research of microscopic structure of bone proved that "carnivorous dinosaurs (theropod) evolved into birds". The thesis was publicized in the article of English scientific journal, "Nature".

The Hayashibara Museum of Natural Sciences will publicize new research information about the relationship between birds and canivorous dinosaurs (theropod) in the article of English scientific magazine, Nature, which will be issued on August 10. The research was collaborately done by curator Masato Watabe of Hayashibara Museum of Natural Sciences and John M.Rensberger of Burke Museum in Seatle, Washington.

	[July 6, 2000]
	First time in the world! Discovered the fossil of a new species of dinosaur with "pygostyle" which is a proof of tail feathers. The dinosaur was named "Nomingia ".

Hayashibra Museum of Natural Sciences found that a fossil, collected by Hayashibara-Mongol joint paleontological expeditions in the Gobi desert in Mongolia in 1994, is highly valuable. The dinosaur possessed "pygostyle (agglutinated bone at the edge of tail)" which was supposed to be connected with feathers. The dinosaur is not an ancestor of birds; however, it is a very interesting specimen because of the fact that a dinosaur, which has no direct genealogical relationship with a bird, independently had a feature of a bird. Furthermore, the dinosaur with "pygostyle" was named "Nomingia=gobiensis" as a new species of dinosaur.

	[May 31, 2000]
	Commencement of Overseas Development of Trehalose - Confirmation of Safety and Conclusion of Letter of Intent with the World's Largest Grain Trader, Cargill, Inc. -

Hayashibara Co., Ltd. signed a letter of intent (LOI) with Cargill, Inc., the world's largest grain trader, for production, marketing and sale of a natural sugar, trehalose, in America. To accomplish this, trehalose has been affirmed as GRAS, which is one of the systems to confirm safety of food ingredients in America. Given this status, Cargill, Inc. will start selling trehalose in America as of June, 2000 and, while evaluating its market potentials and applications, Cargill will carry forward plans to produce trehalose in its own factory in America in the future.Making this LOI as a threshold for overseas trehalose business development, Hayashibara will concretize development of trehalose business in Europe and Asia.

	[March 23, 2000]
	First to sell research reagents for Japanese Cedar (Cryptomeria japonica) pollinosis

On April 1, 2000 Hayashibara Biochemical Labs, Inc. and Asahi Beer Pharmaceutical Co., Ltd. became first companies in the world to sell research reagents for Japanese Cedar (Cryptomeria japonica) pollinosis. Researchers at Hayashibara Biochemical Labs isolated and purified 2 types of Japanese Cedar pollinosis allergens and produced the antibodies. Since these allergens and antibodies are useful in revealing the mechanism of this pollinosis and in developing a treatment, Hayashibara began on sales of the reagents (5 types/11 items) for Japanese Cedar pollinosis though Asahi Beer Pharmaceutical Co., Ltd.