About Us

History

1883
Founded as Hayashibara Shoten (a starch syrup manufacturer) in Okayama, Japan.

1932
Hayashibara Shoten was incorporated on July 10.
1935
Developed the two-step (acid and malt) starch-conversion method for starch syrup production.
1936
Increased daily output of starch syrup to 40 metric tons.

1943
The company's name was changed from Hayashibara Shoten to Hayashibara Co., Ltd.
1945
Entire factory destroyed by an air raid.
1946
Rebuilt factory and resumed operations.
1947
Established Japanese Research Institute for Photosensitizing Dyes Co., Ltd.
1950
Increased the daily output of syrup to 150 metric tons, making Hayashibara the largest starch syrup manufacturer in Japan.

1951
Japanese Research Institute for Photosensitizing Dyes Co., Ltd. launched pharmaceutical products "Lumin A-50 γ tablet" and "Lumin A-100 γ tablet" containing a photosensitizing dye as an active ingredient.
1959
Industrialized the enzymatic production method of glucose from starch.

1960
Constructed a new factory in Okayama, Japan to process 180 metric tons of glucose daily.
1962
Established Hayashibara Shoji, Inc. (Trading Company) for expanding sales of starch syrup and glucose.
1965
Developed the enzymatic saccharification method for maltose.
1967
Discovered Isoamylase, a debranching enzyme that acts on the branching parts of starch molecules (amylopectin).
1968
Developed the production method for high purity maltose (not less than 99%).

Developed the production method for maltitol and licensed it to Anic S.p.A. in 1979.
1969
Developed the production method for glycosylsucrose syrup incorporating the characteristics of sucrose with other properties.
1970
Established Hayashibara Biochemical Laboratories, Inc.
1971
Developed the production method for cyclodextrin (licensed it to Ensuiko Sugar Refining Co., Ltd. in 1987 and to Novo Nordisk in 1998).
1972
Developed the production method for "PULLULAN", a polysaccharide thickener and edible film matrix.
1974
Completed Okayama Plant II in Okayama, Japan.

Launched "SUNMALT", food grade maltose powder.
1976
Began manufacturing "PULLULAN" in a new production unit at Okayama Plant II.
1977
Developed the production method for glucosyl stevia (licensed it to Toyo Sugar Refining Co., Ltd. in 1979 and to Sanyo-Kokusaku Pulp Co., Ltd. in 1982).
1978
Developed the in vivo proliferation method using human cells for the industrial-scale manufacturing of bioactive substances.
1979
Developed the production method for lactosucrose, an oligosaccharide with unique characteristics.
1981
Completed Fujisaki Institute in Okayama, Japan.

Developed the production method for anhydrous crystalline maltitol (licensed it to Towa Chemical Industry Co., Ltd. and Anic S.p.A. in 1982 and to Roquette Frères in 1992).
1983
The Company marked its 100th anniversary.
1985
Completed Fujisaki Cell Center in Okayama, Japan.
1987
Developed the production method for maltotetraose,a starch syrup with pleasant sweetness and reduced off-notes.
Completed Kibi Pharmaceutical Plant & Institute in Okayama, Japan.
1988
Was approved to produce bulk interferon-α, and the interferon-α as a therapeutic drug.
Commercial products were launched by Otsuka Pharmaceutical Co., Ltd. and Mochida Pharmaceutical Co., Ltd.
Japanese Research Institute for Photosensitizing Dyes Co., Ltd. completed Fujita Plant in Okayama, Japan.
Their Imperial Highnesses the Crown Prince Akihito and the Crown Princess Michiko (presently the Emperor and Empress of Japan) honored Kibi Pharmaceutical Plant with a royal visit.
1989
Developed the production method for ascorbic acid 2-glucoside, a stable vitamin C.

Developed the production method for glucosyl hesperidin, a citrus-derived polyphenol.

Developed the production method for glucosyl rutin and licensed it to Toyo Sugar Refining Co., Ltd.
1993
Was approved for the extended application of interferon-α drug, OIF, to treat hepatitis B. The commercial product launched by Otsuka Pharmaceutical Co., Ltd.
Developed the production method for maltosyltrehalose, a carbohydrate with low reducing potential.
1994
Developed the production method for trehalose from starch.

1995
Discovered Interleukin-18 (IL-18), a new bioactive substance.
Launched "TREHA", a high purity trehalose.
Launched "AA2G", a stable vitamin C for cosmetic use.
1997
Won a patent dispute on biotechnology patent with Roche, a company based in Switzerland.
Entered into an exclusive supply contract with the U.S. firm Warner-Lambert Company to supply "PULLULAN" for use in a breath freshening film.
Japanese Research Institute for Photosensitizing Dyes Co., Ltd. completed Fujita Pharmaceutical Plant in Okayama, Japan.
1999
Merged Japanese Research Institute for Photosensitizing Dyes Co. and other companies into Hayashibara Biochemical Labs., Inc.
2000
Their Majesties the Emperor and Empress of Japan honored Fujisaki Institute with a royal visit.
Obtained US FDA GRAS status with "No Questions Letter" for Trehalose U.S.
2001
Entered a global license and supply agreement with Pfizer Inc. for oral applications of "PULLULAN" .
2002
Obtained US FDA GRAS status with "No Questions Letter" for "PULLULAN".
Jointly developed a hard capsule made from "PULLULAN" with Capsugel.

2003
Launched "HALLODEX", a multi-function starch based syrup.
Launched "MG-60", a carbohydrate based material for cosmetics.
2009
Completed Okayama Functional Saccharide Plant in Okayama, Japan.

2011
Hayashibara Co., Ltd., Hayashibara Shoji, Inc., Hayashibara Biochemical Labs., Inc., and Taiyo Estate Co., Ltd. filed for application of the Corporate Rehabilitation Law.
2012
Tokyo District Court approved the reorganization plan filed in 2011.
Hayashibara Co., Ltd. merged Hayashibara Shoji, Inc., and Hayashibara Biochemical Labs., Inc.
NAGASE & CO., LTD. made Hayashibara Co., Ltd. a wholly owned subsidiary.
Received the court decision of completion of the reorganization proceedings.
Okayama Functional Saccharide Plant earned FSSC 22000 certification.
2013
Headquarters, three plants, and two departments earned ISO 9001 certification.
2015
Completed the S Building of Okayama Functional Saccharide Plant in Okayama, Japan.

Completed the New Okayama plant Ⅰin Okayama, Japan.

Launched "Fibryxa" (Main cmponent:Isomaltodextrin), a water soluble dietary fiber.

2016
Obtained US FDA GRAS status with "No Questions Letter" for Isomaltodextrin (Main component of "Fibryxa").