The metabolic effects of trehalose and its analoguesBrian DeBoschWashington University School of Medicine
Information
- Date
- Thursday, September 8, 2022 13:00 - 17:10 *Check-in starts at 12:30 *Online meeting starts at 12:50
- Venue
The symposium features a hybrid format: 1) In-person sola city Conference Center 2F, sola city Hall WEST 4 Chome−6, Kanda Surugadai, Chiyoda City, Tokyo 101-0062 TEL: 03-6206-4855 Visiting sola city: JR Chuō Line, Sōbu Line: Ochanomizu Station 1min. Walk from Hijiribashi Exit TokyoMetro Chiyoda Line: Shin-Ochanomizu Station 0min. Walk from B2 Exit [Direct link to concourse] TokyoMetro Marunouchi Line: Ochanomizu Station 4min. Walk from 1 Exit Toei Shinjuku Line: Ogawamachi Station 6min. Walk from B3 Exit *Please use public transportation as no parking is available. *The admission is on a first-come, first-served basis. 2) Online: Zoom Webinar *Attendees are set muted but can ask questions using the question & answer (Q&A) feature during the webinar. Your understanding is appreciated.
- Symposium
Associates - Sponsor: Hayashibara Co., Ltd. Supporter: The Japanese Society of Applied Glycoscience
- Capacity
- In-person: 200 participants, Online: 1,000 participants
- Admission
- Free of charge (pre-registration required)
- Chairperson
- Takahiro Kikawada, Institute of Agrobiological Sciences (National Agriculture and Food Research Organization (NARO), Senior Principal Scientist)
- Symposium Summary
- Participants: 231 (in-person and online)
Program
Program Summary
Time Schedule | Contents |
|---|---|
13：00 - 13：10 | Opening remarks: Naoki Yasuba (Hayashibara Co., Ltd., Representative Director) |
13：10 - 14：40 | Chairperson: Takahiro Kikawada, Institute of Agrobiological Sciences (National Agriculture and Food Research Organization (NARO), Senior Principal Scientist) I The metabolic effects of trehalose and its analogues (Pre-recorded presentation with a simultaneous interpretation in Japanese.) Brian DeBosch (Washington University School of Medicine, Associate Professor) II Trehalose allows long-term thermal stabilization of vaccines and other biological materials in sugar glasses (Pre-recorded presentation with a simultaneous interpretation in Japanese.) Carlos D. M. Filipe (McMaster University Department of Chemical Engineering, Professor) III Crystallization of a glassy dilute trehalose aqueous solution and its crystal ice transformation process after crystallization. Yoshiharu Suzuki1, Satoshi Takeya²(¹National Institute for Materials Science, Principal Researcher, ²National Institute of Advanced Industrial Science and Technology, Metrology Institute of Japan, Chief Senior Researcher) |
14：40 - 14：50 | Intermission |
14：50 - 16：20 | IV Trehalose in the basic research on cardiac surgery Yasushige Shingu (Department of Cardiovascular Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Lecturer (Cardiovascular Surgery)) V Role of trehalose metabolism in the life history of insects Takashi Nishimura (Institute for Molecular and Cellular Regulation, Gunma University, Professor) IV Crosstalk Pathway between Trehalose Metabolism and Cytokinin Degradation for the Determination of the Number of Berries per Bunch in Grape Shunji Suzuki (The Institute of Enology and Viticulture, University of Yamanashi, Professor) |
16：20 - 16：30 | Intermission |
16：30 - 17：00 | General discussion |
17：00 | Closing remarks Toshiyuki Nishio (Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, Professor / The Japanese Society of Applied Glycoscience, Chairman) |
The contents of the program is subject to change. Please do not take photos or screenshots of the presentation slides.
Abstract
Ⅰ Ⅱ Trehalose allows long-term thermal stabilization of vaccines and other biological materials in sugar glassesCarlos D. M. FilipeMcMaster University Department of Chemical Engineering
Ⅲ Crystallization of a glassy dilute trehalose aqueous solution and its crystal ice transformation process after crystallization.Yoshiharu Suzuki１, Satoshi Takeya２１National Institute for Materials Science, Principal Researcher, 2National Institute of Advanced Industrial Science and Technology, Metrology Institute of Japan
Ⅳ Trehalose in the basic research on cardiac surgeryYasushige ShinguDepartment of Cardiovascular Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
Ⅴ Role of trehalose metabolism in the life history of insectsTakashi NishimuraInstitute for Molecular and Cellular Regulation, Gunma University
Ⅵ Crosstalk Pathway between Trehalose Metabolism and Cytokinin Degradation for the Determination of the Number of Berries per Bunch in GrapeShunji SuzukiThe Institute of Enology and Viticulture, University of Yamanashi
Speakers
Washington University School of Medicine Brian DeBosch Biography
Brian DeBosch is an Associate Professor of Cell Biology & Physiology and Pediatrics at Washington University, Director of the Washington University Nutrition & Obesity Center Enrichment Program, and Director of the Washington University School Digestive Diseases Research Core Center (DDRCC) Section on Metabolic Homeostasis, Nutrient Transport, and Enterohepatic Signaling.
Research
During post-doctoral and early junior faculty epochs, he identified a novel, tractable therapeutic target (hepatic Glucose Transporter 8 (GLUT8)), against non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) pathogenesis. He then defined the mechanism of action of the disaccharide trehalose as a novel glucose transporter inhibitor that recapitulates the effects of GLUT8 deletion in protecting against NAFLD and T2DM by inducing hepatocyte fasting-like responses. He and his team now seek to (i) translate our provocative initial basic discovery to advance human health and longevity; and (ii) define new pathways downstream of glucose transporter signaling so that we can also target these pathways to improve human health.
McMaster University Department of Chemical Engineering Carlos D. M. Filipe Biography
Carlos Filipe joined McMaster University as an Assistant Professor in 2002. Currently is Professor and Chair of the Department of Chemical Engineering.
Research
His research focuses on creating solutions that produce lasting, beneficial effects on society. One example is the work on thermal stabilization of vaccines, which is the focus of his presentation for this event. Another example is the development of "Sentinel Wraps". These wraps are printable DNAzyme-based systems that make typical Saran™ films capable of detecting and reporting the presence of pathogenic bacteria in packaged food, enhancing food safety and security. Carlos has been recognized by McMaster University with an Innovator of Distinction award for his strong track record of transferring technology to the industry. Carlos is also an award-winning instructor. He is a recipient of the President\'s Award for Outstanding Contributions to Teaching and Learning (2011) from McMaster University, which is the highest recognition given at McMaster for teaching and learning.
National Institute for Materials Science Yoshiharu Suzuki Biography
1991 Doctor of Science, Aoyama Gakuin University, Tokyo 1991 Research associate, Aoyama Gakuin University, Tokyo 1997 JSPS Postdoctoral Researcher, National Institute for Research in Inorganic Materials (NIRIM), Tsukuba, Ibaraki 2004 Laboratory Director, FR Co., Tokyo 2008 Principal Researcher, National Institute for Materials and Science (NIMS), Tsukuba, Ibaraki (present)
Research
Polyamorphism of water and aqueous solutions
Department of Cardiovascular Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Yasushige Shingu Biography
2001 Graduate from school of medicine, Hokkaido University 2009 PhD (Graduate School of Medicine, Hokkaido University) 2009 Research and clinical fellow, Leipzig Heart Center, Germany 2011 Assistant professor (Cardiovascular Surgery), Hokkaido University Hospital 2014 Lecturer (Cardiovascular Surgery), Faculty of Medicine and Graduate School of Medicine, Hokkaido University
Research
Trehalose in the basic research on cardiac surgery (heart failure, heart preservation, ischemic reperfusion)
Institute for Molecular and Cellular Regulation, Gunma University Takashi Nishimura Biography
2001 Nara Institute of Science and Technology, Graduate School of Biological Science, master degree 2004 Nagoya University Graduate School of Medicine, Ph.D. 2004 Nagoya University Graduate School of Medicine, JSPF postdoc fellow 2006 Institute for Molecular Biotechnology, Austria, HFSP long-term fellow 2009 RIKEN Center for Developmental Biology, Team Leader2021 Gunma University, IMCR, Professor
Research
Molecular genetic studies of trehalose metabolism in insect.
The Institute of Enology and Viticulture, University of Yamanashi Shunji Suzuki Biography
1991 Mie University, Faculty of Agriculture, Bachelor of Agriculture 1993 Mie University, Graduate School & Faculty of Bioresources, Master of Agriculture 1999 Mie University, Graduate School & Faculty of Bioresources, Ph.D. 1999 University of California, Davis, School of Medicine, Postdoctoral Research Fellow 2002 Akita Prefectural University, Faculty of Bioresource Sciences, Postdoctoral Research Fellow 2003 Ehime University, Assistant Professor2006 University of Yamanashi, Associate Professor 2016 University of Yamanashi, Professor2022 University of Yamanashi, The Institute of Enology and Viticulture, Director
Research
Molecular mechanisms for determining grape berry quality Transgenic approaches in grapevine Characterization of environmental stress-response in grapevineDevelopment of biopesticide for controlling grapevine disease using antagonistic microbes
Chairperson Profile
Institute of Agrobiological Sciences, National Agriculture and Food Research Organization (NARO) Graduate School of Frontier Sciences, The University of Tokyo Takahiro Kikawada Biography
1992 B.Sc., Faculty of Agriculture, Iwate University 1994 M.Sc., United Graduate School of Agricultural Sciences, Iwate University 1994 Researcher, National Institute of Sericological and Entomological Sciences 2001 Chief Researcher, National Institute of Agrobiological Sciences2009 PhD, Tokyo Institute of Technology (Doctorate by way of Dissertation) Supervisor: Prof. SAKURAI Minoru 2015-present Associate Professor, Graduate School of Frontier Sciences, The University of Tokyo 2016 Principal Scientist, Institute of Agrobiological Sciences, NARO 2019-present Senior Principal Scientist, Institute of Agrobiological Sciences, NARO
Research
Molecular mechanisms underlying anhydrobiosis in the sleeping chironomid, Polypedilum vanderplanki Development of dry-preservation technology for animal cells and tissues
Symposium Report
Participants 231 (in-person and online)
The 24th Trehalose Symposium, the first hybrid symposium for in-person and online participants, was met successfully. The numbers of participants are as follows:
Onsite participants: 59, Online participants: 172
During the discussion session, followed by the presentations, Japanese experts shared their viewpoints on why and how most organisms utilize trehalose over other carbohydrates. At the end of the session, the speakers addressed their prospects and expectations for future research and development while indicating the importance of basic research.
Closing Remarks
Toshiyuki Nishio
(Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, Professor / The Japanese Society of Applied Glycoscience, Chairman)
Toshiyuki Nishio (Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, Professor / The Japanese Society of Applied Glycoscience, Chairman)First, I would like to thank the six researchers for sharing their findings and Dr. Kikawada for chairing this symposium. I would also like to thank all on-site and online attendees for being part of the Trehalose Symposium. As a carbohydrate researcher, I was intrigued to discover that a single oligosaccharide features diverse functionalities in various applications elaborately presented by the speakers. I recall that trehalose was initially evaluated as a carbohydrate-based ingredient in the food industry, but currently, it is also studied as a material inducing bioactivities. R & D work on beneficial applications of trehalose will progress unlimited to specific fields or industries.
However, research on trehalose-inducing bioactivities should go further than identifying applications or usefulness. In other words, I suggest reevaluating basic research, which identifies the mechanisms behind such applicability and utility at the molecular level. Basic research unveils the true nature of a particular substance and what it does, promoting applied research followed by active implementations in various fields. I cannot stress enough the importance of basic research to discover mechanisms behind physiological effects.
Last week in Tokyo, some distinguished researchers, represented by Dr. Keiji Kainuma, led the seminars at the 70th-anniversary meeting of the Japanese Society of Applied Glycoscience, of which I serve as the chairman. Dr. Kainuma’s presentation featured a group photo with acclaimed researchers, including the late Dr. Hidemasa Hidaka, known for fructooligosaccharide research. I noticed the sign "The First Trehalose Symposium” hanging above the celebrated scientists. A sense of pride and appreciation filled my heart through the visual evidence that well-respected researchers were actively engaged with the Trehalose Symposium. Many researchers made presentations from the very first session in 1997 to the latest 24th session. Some discoveries were implemented while others were not. Considering its valuable history, I believe the continuation of the Trehalose Symposium is critical. Although many unknowns are yet to be explored in trehalose research, I encourage all of you to stand on top of the accumulated knowledge from the past 24 sessions while revisiting the valuable ideas and clues from the discussion session one at a time. I sincerely hope the Trehalose Symposium nourishes your future research.
Lastly, I would like to conclude my speech by wishing you all continued success and prosperity. Thank you.
＜Biography＞
1981 Graduated from the Faculty of Science, Saitama University.
1983 Completed Graduate School of Agriculture, Tokyo University of Agriculture and Technology.
1983 Belonging to the Applied Development Lab., Sapporo Breweries.
1989 Seconded to the Faculty of Pharmaceutical Sciences, Tokyo University. (for 2 years)
1990 Acquisition of PhD (Tohoku University)1993 Belonging to the College of Bioresource Sciences, Nihon University.
1997 Studied abroad to the National Research Council of Canada. (for 1 year)
2011 Appointed as a professor2021 Became chairman of the Japanese Society of Applied Glycoscience.
＜Research＞
Chemistry and Biological Science of Carbohydrate