Research and Development

Research Papers

2018

OtherStructural features of a bacterial cyclic α-maltosyl-(1→6)-maltose (CMM) hydrolase critical for CMM recognition and hydrolysis

Journal of Biological Chemistry 2018 Oct 26;293(43):16874-16888

Masaki Kohno, Takatoshi Arakawa*1, *2, Hiromi Ota*3, Tetsuya Mori, Tomoyuki Nishimoto, Shinya Fushinobu*1, *2

*1 Department of Biotechnology, The University of Tokyo
*2 Collaborative Research Institute for Innovative Microbiology, The University of Tokyo
*3 Advanced Science Research Center, Okayama University

HealthcareNK-4 exerts selective regulatory effects on the activation and function of allergy-related Th2 cells

PLoS One 13(6), e0199666 (2018)

Keizo Kohno, Satomi Koya-Miyata, Akira Harashima, Toshio Ariyasu, Shimpei Ushio

FoodEffects of isomaltodextrin in postprandial lipid kinetics: Rat study and human randomized crossover study

PLoS One 13(5) e196802 (2018)

Ryodai Takagaki, Yuki Ishida, Tsuyoshi Sadakiyo, Yoshifumi Taniguchi, Takeo Sakurai, Hitoshi Mitsuzumi, Hikaru Watanabe, Shigeharu Fukuda, Shimpei Ushio

2017

CosmeticEffects of a non-cyclodextrin cyclic carbohydrate on mouse melanoma cells: Characterization of a new type of hypopigmenting sugar

PloS one 12(10) e0186640 (2017)

Shuji Nakamura, Toshio Kunikata, Yohsuke Matsumoto, Toshiharu Hanaya, Akira Harashima, Tomoyuki Nishimoto, Shimpei Ushio.

FoodThe attenuating effect of isomaltodextrin on postprandial blood glucose level in healthy human subjects: a randomized, placebo-controlled, double-blind crossover study

JAPANESE PHAMACOLOGY & THERAPEUTICS 45(7), 1179-1185 (2017)

Yuki Ishida, Tsuyoshi Sadakiyo, Shin-ichiro Inoue, Hikaru Watanabe, Hitoshi Mitsuzumi, Shigeharu Fukuda, Shimpei Ushio, Jun-ichi Hiramatsu*

* Hiramatsu Clinic

FoodIsomaltodextrin prevents DSS-induced colitis by strengthening tight junctions in mice

Food Science and Technology Research, 23(2), 305-317 (2017)

Chikako Arai, Takeo Sakurai, Satomi Koya-Miyata,Shigeyuki Arai, Yoshifumi Taniguchi, Takashi Kamiya, Chiyo Yoshizane, Kazue Tsuji-Takayama, Hikaru Watanabe, Shimpei Ushio and Shigeharu Fukuda

FoodSafety assessment of a soluble dietary fiber, isomaltodextrin, enzymatically produced from starch

Fundamental Toxicological Sciences 4(2), 57-75 (2017)

Tsuyoshi Sadakiyo, Shin-ichiro Inoue, Yuki Ishida, Hikaru Watanabe, Hitoshi Mitsuzumi, Shimpei Ushio

FoodAttenuation of postprandial blood glucose in humans consuming isomaltodextrin: carbohydrate loading studies

Food & Nutrition Research 61(1), 1325306 (2017)

Tsuyoshi Sadakiyo, Yuki Ishida, Shin-ichiro Inoue, Yoshifumi Taniguchi, Takeo Sakurai, Ryodai Takagaki, Mayumi Kurose, Tetsuya Mori, Akiko Yasuda-Yamashita, Hitoshi Mitsuzumi, Michio Kubota, Hikaru Watanabe, Shigeharu Fukuda

FoodThe Effect of a Beverage Containing Isomaltodextrin on Bowel Movements in Healthy Subjects: A Randomized, Double-blind, Placebo-controlled, Crossover Study

JAPANESE PHAMACOLOGY & THERAPEUTICS 45(4), 609-616 (2017)

Yuki Ishida, Tsuyoshi Sadakiyo, Hikaru Watanabe, Hitoshi Mitsuzumi, Shimpei Ushio, Isao Takehara*1, Kazuhiko Takano*2

*1 Clinical Support Corporation Ltd.
*2 Medical Corporation Hokubu-kai Utsukushigaoka Hospital

FoodGlycemic,insulinemic and incretin responses after oral trehalose ingestion in healthy subjects

Nutrition Jounal 16:9 (2017) DOI 10.1186/s12937-017-0233-x

Chiyo Yoshizane, Akiko Mizote, Mika Yamada, Norie Arai, Shigeyuki Arai, Kazuhiko Maruta, Hitoshi Mitsuzumi, Toshio Ariyasu, Shimpei Ushio, Shigeharu Fukuda

FoodImprovement on bowel movement by isomaltdextrin in women - A double-blind crossover placebo-controlled study-

JAPANESE PHAMACOLOGY & THERAPEUTICS 45(2), 201-209 (2017)

Shin-ichiro Inoue, Tsuyoshi Sadakiyo, Yuki Ishida, Hikaru Watanabe, Hitoshi Mitsuzumi, Shigeharu Fukuda, Shimpei Ushio, Makoto Terashima*1, Naoki Miura*2

*1 Oneness Support Co. Ltd.
*2 Miura Clinic

2016

FoodDaily intake of trehalose is effective in the prevention of lifestyle-related diseases in individuals with risk factors for metabolic syndrome

Journal of Nutritional Science and Vitaminology, 62(6), 380-387 (2016)

Akiko Mizote, Mika Yamada, Chiyo Yoshizane, Norie Arai, Kazuhiko Maruta, Shigeyuki Arai, Shin Endo, Rieko Ogawa, Hitoshi Mitsuzumi, Toshio Ariyasu, Shigeharu Fukuda

HealthcareTumor-specific delivery of biologics by a novel T-cell line HOZOT

Scientific Reports 6, 38060 (2016)

Teppei Onishi*1, Hiroshi Tazawa*1,2, Yuuri Hashimoto*1, Makoto Takeuchi, Takeshi Otani, Shuji Nakamura, Fuminori Sakurai*3, Hiroyuki Mizuguchi*3, Hiroyuki Kishimoto*1, Yuzo Umeda*1, Yasuhiro Shirakawa*1, Yasuo Urata*4, Shunsuke Kagawa*1 and Toshiyoshi Fujiwara*1

*1 Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
*2 Center for Innovative Clinical Medicine, Okayama University Hospital
*3 Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University
*4 Oncolys BioPharma, Inc.

HealthcareCholesteryl pullulan nanoparticles-encapsulated TNF-α: an effective mucosal vaccine adjuvant against influenza

"Steps Forwards in Diagnosing and Controlling Influenza" edited by Manal Mohammad Baddour, InTech, 139-159 (2016)

Tsunetaka Ohta

FoodInvolvement of splenic iron accumulation in the development of nonalcoholic steatohepatitis in Tsumura Suzuki Obese Diabetes mice

Scietific Reports 6, 22476 (2016)

Kazutoshi Murotomi*, Shigeyuki Arai, Satoko Uchida, Shin Endo, Hitoshi Mitsuzumi, Yosuke Tabei*, Yasukazu Yoshida*, and Yoshihiro Nakajima*

* Health Research Institute, National Institute of Advanced Industrial Science and Technology

FeedEffects of trehalose supplementation on the growth performance and intestinal innate immunity of juvenile chicks

British Poultry Science 57(3), 375-380 (2016)

Motoi Kikuzato*, Fumika Nanto*, Kazuhisa Mukai, and Masaaki Toyomizu*

* Animal Nutrition, Life Sciences, Graduate School of Agricultural Science, Tohoku University

2015

FoodDietary glucosyl hesperidin improves skin color and skin conditions in women. -Placebo-controlled double-blind comparative study-

Japanese Pharmacology & Therapeutics 43(12), 1687-1699 (2015)

Shin Endo, Hitoshi Mitsuzumi, Satoko Uchida, Kazuhiko Maruta, Toshio Ariyasu, Shigeharu Fukuda, Ryoma Shimizu*1, Ryuji Takeda*2, Chihiro Shikata*3

*1 TES Holdings Co., Ltd.
*2 Yokohama University of Pharmacy
*3 Clintexe Clinic

OtherAnti-inflammatory effects of adenosine N1-oxide.

Journal of Inflammation 12(1), 2-17 (2015)

Keizo Kohno, Emiko Ohashi, Osamu Sano, Hajime Kusano, Toshio Kunikata, Norie Arai, Toshiharu Hanaya, Toshio Kawata, Tomoyuki Nishimoto, Shigeharu Fukuda

HealthcareCholesteryl pullulan encapsulated TNF-α nanoparticles are an effective mucosal vaccine adjuvant against influenza virus.

BioMed Research International Article ID 471468 (2015)

Daiki Nagatomo, Madoka Taniai, Harumi Ariyasu, Mutsuko Taniguchi, Miho Aga, Toshio Ariyasu, Tsunetaka Ohta, Shigeharu Fukuda